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Table 2 Mnemiopsis homologs to ciliary and rhabodmeric phototransduction cascade components and their reciprocal best BLAST hit.

From: Genomic organization, evolution, and expression of photoprotein and opsin genes in Mnemiopsis leidyi: a new view of ctenophore photocytes

Protein name (GenBank accession number of query protein) GenBank accession number of top
Mnemiopsisresult (ML identifier)
E-value Reciprocal best BLAST query result
Protein name [Species; GenBank accession number]
E-value RNA-seq
Evidence?
Ciliary components
Opsin (ACB05673) JQ724646
(ML13055)
2e-22 Opsin-3-like [Oreochromis niloticus; XP_003441288] 6e-31 Yes
G-alpha-s subunit (BAA81697) JX564543
(ML012011)
1e-93 guanine nucleotide binding protein, alpha stimulating activity polypeptide [Daphnia pulex; EFX88427.1] 3e-177 Yes
G-alpha-i subunit (ACB05685.1) JQ724654
(ML156514)
2e-129 G protein alpha subunit i class [Halocynthia roretzi; BAB79197.1] 2e-177 Yes
Transducin G-alpha-t1 (AAB01735_1) JX564546
(MLRB156557)
9e-73 guanine nucleotide-binding protein G(i) subunit alpha-2 [Mus musculus; NP_032164.2] 3e-173 Yes
Transducin G-gamma-t1 (AAH25929_1) JX564547
(ML17031)
7e-07 guanine nucleotide-binding protein G(T) subunit gamma-T1 [Otolemur garnettii; XP_003782721] 1e-06 Yes
GRK1 G protein-coupled receptor kinase 1 (AAH96611_1) JX564550
(MLRB009169)
9e-110 G protein-coupled receptor kinase 5 [Callithrix jacchus; XP_002756686] 0.0 No
GMP-PDE alpha rod (NP_666198_1); GMP-PDE beta rod (P23440_3) JX564548
(MLRB03248)
1e-97;
5e-99
sperm phosphodiesterase 5-like [Saccoglossus kowalevskii; XP_002733933] 0.0 Yes
GMP-PDE delta (O55057_1) JX564549
(ML233327a)
6e-55 cGMP-specific rod phosphodiesterase 6D delta [Trichoplax adhaerens; XP_002113713] 8e-55 Yes
Phosphodiesterase (ACB05690) JQ724657
(ML096829)
4e-105 High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A-like [Danio rerio; XP_692819.2] 1e-163 Yes
Cyclic nucleotide gated ion channel (CAB42891.1) JX564544
(ML08605)
and
JX564545
(ML054419)
2e-105
1e-115
cGMP-gated cation channel alpha-1-like, partial [Cricetulus griseus; XP_003515326]
predicted protein [Nematostella vectensis; XP_001641603.1]
2e-124
1e-121
Yes
RGS9-1 regulator of G-protein signaling 9 isoform 1 (NP_035398_2) JX564552
(MLRB369320)
2e-14 regulator of G-protein signaling loco-like [Megachile rotundata; XP_003705980] 1e-27 No
GC1 guanylyl cyclase GC-E precursor (NP_032218_2) JX564553
(ML17474)
2e-131 natriuretic peptide receptor 1-like [Saccoglossus kowalevskii; XP_002734106] 0.0 Yes
Recoverin (NP_033064_1);
GCAP1 guanylyl cyclase-activating protein 1 (NP_032215_2);
GCAP2 guanylyl cyclase-activating protein 2 (NP_666191_1)
JX564551
(ML096819)
9e-51;
1e-32;
2e-38
Hypothetical protein DAPPUDRAFT_65663 [Daphnia pulex; EFX65172] 2e-121 Yes
Rhabdomeric components
G-alpha-q subunit (ACB05683) JQ724653
(ML009153)
4e-105 Heterotrimeric GTP-binding protein alpha subunit G-alpha-q [Litopenaeus vannamei; AAT44837.1] 8e-134 Yes
Phospholipase C (ACB05675) JQ724649
(ML04921)
1e-178 Predicted protein [Nematostella vectensis; XP_001635876.1] ≤1e-1000 Yes
Trp-C protein (ACB05689) JQ724656
(ML234550)
1e-11 Similar to TRP gamma cation channel [Nasonia vitripennis; XP_001604587.1] 1e-53 Yes
Shared components
Visual G beta (ACB05681) JQ724652
(ML02234)
7e-162 G-protein beta subunit [Meloidogyne javanica; ACB97665.1] ≤1e-1000 Yes
Rhodopsin kinase (ACB05677) JQ724650
(ML04904)
8e-85 Beta-adrenergic receptor kinase 2 [Danio rerio; NP_001128197.1] ≤1e-1000 Yes
Arrestin (ACB05679 and P20443_1) JQ724651
(ML047926)
4e-55 TRIADDRAFT_64255 [Trichoplax adhaerens; XP_002116188.1] ≤1e-1000 Yes
Retinal-binding protein (ACB05687) JQ724655
(ML167044)
2e-28 Similar to SEC14-like protein 1 isoform 4 [Canis familiaris; XP_857362.1] ≤1e-1000 Yes
  1. For each query protein, the corresponding Mnemiopsis protein model is listed with the E-value of the top BLAST result. The Mnemiopsis protein model was then used as a query in a reciprocal best BLAST search of the non-redundant protein database (NCBI) and the top result is listed along with the E-value of the BLAST result. RNA-seq data supports the developmental mRNA gene expression of each of these protein models. BLAST: Basic Local Alignment Search Tool; ML: Mnemiopsis leidyi; PDE: phosphodiesterase; TRP: transient receptor potential.