Figure 3From: Imbalance of heterologous protein folding and disulfide bond formation rates yields runaway oxidative stressTranscription factors activated by recombinant protein secretion. Transcription factors were scored based on significantly changed genes in (a) wild-type strains, and (b) Δhac1. Venn diagram shows the number of secretory-related transcription factors activated in insulin precursor and α-amylase compared to no protein secretion. Table lists secretory-related transcription factors in small (insulin precursor) and large (α-amylase) protein secretion. Color coding indicates common secretory mechanisms as shown in diagram: modifying trans-Golgi network sorting (orange), oxidative stress (purple), amino acid metabolism (blue), and transcription and translation (green).Back to article page