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Figure 2 | BMC Biology

Figure 2

From: Clamp loader ATPases and the evolution of DNA replication machinery

Figure 2

Clamp loaders place sliding clamps at primer-template junctions for processive DNA replication. When bound to ATP, clamp loaders are competent to bind and open the sliding clamp protein. This ternary complex can now bind to a primer-template junction, which activates the ATPase activity of the clamp loader. ATP hydrolysis causes the clamp loader to dissociate from the clamp and DNA, resulting in a loaded clamp that is competent for acting as a processivity factor for DNA polymerase. Figure adapted from [60].

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