|MSCI||(1) X → A retrogenes with testis biased expression ||(2) Under-representation of male/testis-biased genes on the X |
|MSCI as driving force (pros/cons)||
Down-regulation of testis-specific insertions in the X. Use a single promoter [24, 29].|
Down-regulation of X in meiosis. Use mixture of cells .
Down-regulation of X in wild-type testis as opposed to bam mutant testis . bam mutant also show small degree of down regulation .
|Complementary expression in meiosis for X → A Retrogene .||Under-representation of male-meiotic expressed genes in the X .|
|MSCI NOT as driving force (pros/ cons)||No global down regulation of the X chromosome in developing testis . No statistical supporta.||Retrogenes with general female or unbiased expression . No expression data support.||General tissue-specific under-representation on the X . Tissue-specific genes are enriched with testis-biased genesa.|