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Table 1 General features of the transcriptional response to genome mistranslations

From: Low level genome mistranslations deregulate the transcriptome and translatome and generate proteotoxic stress in yeast

GO term

Genes in term

T40' genes

P-value

T60' genes

P-value

T90' genes

P-value

T120' genes

P-value

T180' genes

P-value

protein targeting to mitochondrion

53

18

3·10-10

        

regulation of protein metabolic process

276

48

2·10-12

  

35

3·10-10

  

51

2·10-25

transposition

135

  

32

3·10-22

40

2·10-25

28

2·10-20

  

macromolecule biosynthetic process

1675

106

4·10-10

  

106

3·10-9

  

133

8·10-32

vacuolar protein catabolic process

118

  

15

5·10-7

15

4·10-5

15

2·10-8

14

3·10-5

response to heat

198

21

5·10-3

16

8·10-5

19

2·10-4

19

3·10-8

17

3·10-4

response to toxin

31

  

5

1·10-3

  

5

5·10-4

8

5·10-6

translation

731

124

3·10-32

  

102

2·10-35

32

5·10-5

131

4·10-75

regulation of translation

190

47

2·10-18

    

11

3·10-3

50

1·10-32

regulation of translational fidelity

15

    

5

2·10-4

3

3·10-3

7

2·10-7

maturation of SSU-rRNA

94

    

20

3·10-10

8

7·10-4

26

1·10-17

ribosome assembly

69

13

1·10-4

  

16

4·10-9

  

24

5·10-19

ribosome biogenesis

360

33

6·10-3

  

43

1·10-11

16

4·10-3

60

1·10-27

  1. For each of the time-point DEGs, a hypergeometric test was applied over each GO biological process (R package GOstats), selecting GO terms with P-value lower than 10-3. The GO terms considered for mistranslations are either enriched for four or more time points, or have a significance level below a P-value of 10-9 for a single time point. This method provides about 40 GO terms that, after manually removing redundant and generic terms, result into the terms displayed in Table 1.