Role of neurotransmitter signaling in sensation of noxious thermal stimuli. Changes in median speed are plotted against time for (A) different alleles of gene encoding glutamate transporter (eat-4) and transgenic glutamate transporter mutant (eat-4(ky5) expressing EAT-4 under the odr-3 promoter (eat-4(ky5) rescue). (B) Animals harboring mutations in glutamate gated channels, glr-2 and glc-3. (C) Strains defective in neuropeptide processing pathway. Speed profiles of animals harboring mutations in egl-3 and egl-21 are plotted at the indicated ΔT. (D) Animals harboring loss-of-function mutations in cat-1 and unc-80 genes. (E) Ethograms of unc-80(e1069) at the indicated ΔT. Each row represents behavior of a single animal over time. Color scheme is same as Figure 2B.