TY - JOUR AU - Chaiyachati, Barbara H. AU - Kaundal, Ravinder K. AU - Zhao, Jiugang AU - Wu, Jie AU - Flavell, Richard AU - Chi, Tian PY - 2012 DA - 2012/11/30 TI - LoxP-FRT Trap (LOFT): a simple and flexible system for conventional and reversible gene targeting JO - BMC Biology SP - 96 VL - 10 IS - 1 AB - Conditional gene knockout (cKO) mediated by the Cre/LoxP system is indispensable for exploring gene functions in mice. However, a major limitation of this method is that gene KO is not reversible. A number of methods have been developed to overcome this, but each method has its own limitations. SN - 1741-7007 UR - https://doi.org/10.1186/1741-7007-10-96 DO - 10.1186/1741-7007-10-96 ID - Chaiyachati2012 ER -