TY - JOUR AU - Gidalevitz, Tali AU - Wang, Ning AU - Deravaj, Tanuja AU - Alexander-Floyd, Jasmine AU - Morimoto, Richard I. PY - 2013 DA - 2013/09/30 TI - Natural genetic variation determines susceptibility to aggregation or toxicity in a C. elegansmodel for polyglutamine disease JO - BMC Biology SP - 100 VL - 11 IS - 1 AB - Monogenic gain-of-function protein aggregation diseases, including Huntington’s disease, exhibit substantial variability in age of onset, penetrance, and clinical symptoms, even between individuals with similar or identical mutations. This difference in phenotypic expression of proteotoxic mutations is proposed to be due, at least in part, to the variability in genetic background. To address this, we examined the role of natural variation in defining the susceptibility of genetically diverse individuals to protein aggregation and toxicity, using the Caenorhabditis elegans polyglutamine model. SN - 1741-7007 UR - https://doi.org/10.1186/1741-7007-11-100 DO - 10.1186/1741-7007-11-100 ID - Gidalevitz2013 ER -