Figure 1

Analysis of the 5.5 kb genomic DNA sequences of the potential mouse Tbx4 lung enhancer. (A) Placental mammal basewise conservation scores determined by phyloP program [11]. Positive scores are assigned to the sites with conserved DNA sequences among the studied vertebrate species, which include mouse, rat, kangaroo rat, naked mole rat, guinea pig, squirrel, rabbit, pika, human, chimp, gorilla, orangutan, gibbon, rhesus, baboon, marmoset, squirrel monkey, tarsier, mouse lemur, bushbaby, treeshrew, pig, alpaca, dolphin, sheep, cow, cat, dog, panda, horse, microbat, megabat, hedgehog, shrew, elephant, rock hyrax, tenrecs, manatee, armadillo, sloth, opossum, Tasmanian devil, wallaby, platypus, turkey, chicken, zebra finch, budgerigar, lizard, painted turtle, xenopus tropicalis, coelacanth, tetraodon, fugu, nile tilapia, stickleback, medaka, Atlantic cod, zebrafish, lamprey. (B) The related sequence alignments of the above vertebrates to mouse Tbx4 genomic DNA sequence by Multiz program [12]. Most sequence alignments were omitted due to limited space. Identical nucleotide sequences are indicated by vertical black bar.