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Figure 10 | BMC Biology

Figure 10

From: Lung mesenchymal expression of Sox9plays a critical role in tracheal development

Figure 10

Concept diagram of Sox9 function in lung development. Sox9 acts downstream of Tbx4/5[6]. Sox9 feeds back negatively on Tbx4 and Tbx5 in the tracheal mesenchyme. Cartilage ring formation requires functional Sox9 expression in the tracheal mesenchyme. Lack of cartilage rings induce altered tracheal epithelium differentiation (increased Clara cells, and decreased basal and goblet cells) and defective development of tracheal vasculature structurest.

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