Identification of the sea star Patiria miniata ParaHox orthologs. (A) Alignment of the homeodomains of the three P. miniata ParaHox genes with representative invertebrate and vertebrate orthologs. Broken lines indicate amino acid identities; the position of PmCdx intron within the homeodomain is indicated by a vertical arrow. The names of the species are: Sp (Strongylocentrotus purpuratus); Pf (Ptychodera flava); Ci (Ciona intestinalis); m (Mus musculus); Dfd (Drosophila melanogaster); Xl (Xenopus laevis); Htr (Helobdella triserialis); Bf (Branchiostoma floridae). ind and caudal are the Drosophila melanogastervorthologs of Gsx and Cdx respectively. (B) The genomic organization of P. miniata ParaHox genes is represented in scale showing separate exons for each gene. Asterisks indicate the homeobox in each gene. kb: kilobases.