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Figure 3 | BMC Biology

Figure 3

From: Pronounced cancer resistance in a subterranean rodent, the blind mole-rat, Spalax: in vivo and in vitroevidence

Figure 3

3MCA-induced tumor in Spalax . (A) Light microscopic examination. Note spindle, epithelioid and giant multinuclear cells (empty arrow); nuclei are variable in shape, size and chromatin distribution; nucleoli vary in frequency. Hematoxylin and eosin staining, ×100. (B) Transmission electron microscopy (TEM): dilated, elongated rough endoplasmic reticulum (black arrows) and abundant collagen fibers (white arrows) (C) TEM: a giant, monstrous nucleus (N). (D) Cell line established from Spalax tumor, phase contrast image after six months of continuous cultivation (×200). 3MCA, 3-Methylcholantrene.

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