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Table 1 Gene, function and number of Oct and Oct-like/nub sites in the 5′ upstream region

From: The Oct1 homolog Nubbin is a repressor of NF-κB-dependent immune gene expression that increases the tolerance to gut microbiota

A. Oct sites in immune and stress response genes with ≥2 fold change in carcass or gut (a)

Gene

Computed gene number

Function

Fold change carcass

Fold change gut

Oct sites

Oct-like /nub

CecA1

CG1365

Antimicrobial peptide

>10b

>10b

3

2

CecB

CG1878

Antimicrobial peptide

5.5

−1.4

1

 

CecC

CG1373

Antimicrobial peptide

13

b.b.

2

 

AttC

CG4740

Antimicrobial peptide

45

14

2

1

AttD

CG7629

Antimicrobial peptide

8.1

−1.9

 

1

Def

CG1385

Antimicrobial peptide

15

1.7

2

 

Dpt

CG12763

Antimicrobial peptide

>10b

4b

1

 

Dpt B

CG10794

Antimicrobial peptide

2.7

−1.4

3

 

Drosocin

CG10816

Antimicrobial peptide

18

4.4

1

1

Drs

CG10810

Antimicrobial peptide

4.9

1.1

1

 

Dro2

CG32279

Antimicrobial peptide

b.b

4.1

3

 

Dro3

CG32283

Antimicrobial peptide

b.b

2.2

1

 

Dro4

CG32282

Antimicrobial peptide

−2.5

−2.2

1

 

Dro5

CG10812

Antimicrobial peptide

−1.2

−7.9

2

1

Listericin

CG9080

Antimicrobial peptide

4.4

−1.7

2

 

Mtk

CG8175

Antimicrobial peptide

2.5

1.5

3

1

Anp

CG1361

Antimicrobial peptide

b.b

154

5

 

LysX

CG9120

Antimicrobial protein

b.b

−17

3

 

IM23

CG15066

Immune molecule

21

3.5

2

1

IM10

CG18279

Immune molecule

−20

−26

2

1

PGRP-SC2

CG14745

Recognition

4.8

1.1

3

 

PGRP-SB1

CG9681

Recognition

4.8

1.5

1

 

PGRP-LD

CG32912-RB/RA/RD

Recognition

4.6

1.8

1

 

2

 

PGRP-LC

CG4432

Recognition

3.8

2.9

2

 

PGRP-LB

CC14704-RA/RC/RD

Recognition

3.3

2.6

4

 

5

 

4

1

Tep II

CG7052

Recognition

2.7

1.6

2

 

Tep IV

CG10363

Recognition

2.4

1.8

4

 

GNBP3

CG5008

Recognition

−2.1

−3.9

3

 

Sr-CIV

CG3212

Scavenger receptor

b.b

11

1

1

Galpha49B

CG17759-RD/RE

Signaling

2.5

4.2

3

1

Pirk

CG15687

Signaling

2.5

4.3

5

 

Prx2540-2

CG11765

Peroxiredoxin

2.0

−1.4

1

 

Tsf1

CG6186

Iron sequestration

2.9

2.1

2

 

TotX

CG31193

Stress peptide

3.3

2.9

2

 

TotM

CG14027

Stress peptide

2.1

2.2

3

 

B. Oct sites in immune genes and in house-keeping genes with no significant fold change in carcass or gut (a)

Dro 6

CG32268

Antimicrobial peptide

1.2

1.0

–

–

Drs-like

CG32274

Antimicrobial peptide

1.2

1.1

–

–

Bsk

CG5680

JNK Signaling

1.1

−1.3

–

–

Gapdh1

CG12055

Glycolys

1.2

1.1

–

–

Rpl32/rp49

CG7939

Ribosomal protein

−1.1

−1.1

1

–

Act5C

CG4027

Actin

1.1

1.2

–

–

Aats-arg

CG9020

Arginine tRNA syntase

1.0

−1.1

–

–

  1. Consensus sequence of Oct sites: AT(C,G)(C,G,T)AAA(A,T) and of the Oct-like/nub site: ATTCAAAT. Fold change indicates mRNA expression levels in gut and carcass, comparing wild type versus nub1 mutant, data taken from the microarray data in Additional files 5 and 8 unless other wise indicated. Non-reliable values due to concentrations below background have been removed. A longer list of analyzed genes including the positions of the Oct sites is presented as Additional file 11. aLocation of sites within 2000 bp from the transcription start site of respective gene or up to the nearest exone of an adjacent gene. bData taken from RT-qPCR results (Figures 1 and 3). b.b., concentrations below background.
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BMC Biology

ISSN: 1741-7007

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