pAKT response of IGF-1 is negatively correlated with pErbB2 basal level. (A) Correlation of pAKT fold-change response in cells exposed to 100 ng/ml IGF-1 plotted as in 5A. (B) Distribution of relevant RTK expression or phosphorylation levels between lines exhibiting significant (red) or not significant (gray) pAKT response to IGF-1. Black lines represent the median, shaded zones the interquartile range, dashed lines the 5% and 95% quantiles, and dots the outliers. P-values were assessed by a Wilcoxon rank-sum test. (C) Projection of IGF1R and pErbB2 levels in each cell line overlaid with pAKT fold-change response in cells exposed to IGF-1.