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Table 1 TCR α and β chain repertoires of a Th1 polarized T cell line

From: Elongated TCR alpha chain CDR3 favors an altered CD4 cytokine profile

  

CDR3 region

 

CDR3 length

%

TCR alpha

EDSAIYFC

AASREGTGSKLS

FGKG

12

34

SDSAKYFC

ALEGRGGRALI

FGTG

11

20

EDSGTYFC

AALPGTGSNRLT

FGKG

12

18

GDSAMYFC

AAKNSGTYQR

FGTG

10

8

GDSAIYFC

SASMTNNNNRIF

FGDG

12

6

EDSGTYFC

AADSNYQLI

WGSG

9

4

EDSGTYFC

AAETNSAGNKLT

FGIG

12

2

EDSGTYFC

AADSNHQLI

FGSG

9

2

EDSGTYFC

AAEAANYNVLY

FGSG

11

2

EDSAIYFC

AASKPNNRIF

FGDG

10

2

SDSAVYFC

ALSALGTGNYKYV

FGAG

13

2

TCR beta

DDSATYFC

ASSQGPLSNERLF

FGHG

13

22

NEMAVLFC

ASSRSGDQDTQY

FGPG

12

18

EDSAVYLC

ASSRDWGDTQY

FGPG

11

14

DDSATYFC

ASSQEMQGQDTQY

FGPG

13

6

EDSAVYLC

ASSPWGVQDTQY

FGPG

12

4

QDSAVYLC

ASSLAGQGARSQNTLY

FGAG

16

4

SQTSLYFC

ASSPGSNERLF

FGHG

11

4

KDSAVYLC

ASSLVGAEQF

FGPG

10

4

DDSATYFC

ASSKAGTGEDTQY

FGPG

13

2

DDSATYFC

ASSQQGDQDTQY

FGPG

12

2

DDSATYFC

ASSQEGTGVQDTQY

FGPG

14

2

DDSATYFC

ASSQEGTGGDEQY

FGPG

13

2

DDSATYFC

ASSQEGLSSYEQY

FGPG

13

2

DDSATYFC

ASSQEGLGNYEQY

FGPG

13

2

DDSATYFC

ASSQEMQGDQDTQY

FGPG

14

2

QDSAVYLC

ASSNQNYAEQF

FGPG

11

2

QDSAVYLC

ASSSRDWGDEQY

FGPG

12

2

EDSAVYFC

ASSQAGTDTQY

FGPG

11

2

EDSAVYFC

ASSSPGGSYEQY

FGPG

12

2

SQTSVYFC

ASGDSQGANQAPL

FGEG

13

2

  1. T cell lines were maintained in culture for one round of re-stimulation under highly polarizing conditions before taking RNA for TCR sequence analysis. TCRα and β chain repertoire analysis of an H2-Ag7/PLP 56-70 specific Th1, Th2 and Th17 cell lines shows expansion of distinct, dominant TCRα chains in the absence of a dominant β chain. The frequency (%) of each unique TCR sequence identified is shown. CDR3 length is defined as the number of amino acids between the invariant C residue and the F/W-G-X-G motif. TCRα and TCRβ CDR3 region lengths are shown in each table. Data are representative of 50 TCRα and 50 TCRβ sequences for each T cell line. The mean CDR3 length for the TCRα chain is 12.2 ± 0.2 (SE) for Th2 cultures, 11.4 ± 0.1 (SE) for Th1 cultures, and 11.1 ± 0.1 (SE) for Th17 cultures.
  2. The most dominant TCR alpha sequence is shown in bold.
  3. Mean CDR3α length 11.42 + 0.13 (SE) (n = 50).
  4. Mean CDR3β length 12.30 + 0.17 (SE) (n = 50).