Domain structure of E. multilocularis insulin receptors. Schematic representation of the domain structures of the human insulin receptor (HIR), EmIR1 and EmIR2 according to SMART analyses (Letunic et al., 2012). Displayed are the location and size of the following predicted domains: TKD, tyrosine kinase domain; LBD, ligand binding domain; RL, receptor-L-domain; FU, furin-rich repeat; Fn3, fibronectin 3 domain. The presence of NPXY-motifs for binding of IRS is indicated by an arrowhead. Red bars at the N-terminus represent signal peptides, orange bars represent transmembrane domains. IRS, insulin receptor substrate; SMART, Simple Modular Architecture Research Tool.