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Table 2 Effect of combining the exonuclease and active site mutations in DNA polymerase ε on mutation rates in diploids. Mismatch repair proficient strains

From: Evidence for interplay among yeast replicative DNA polymerases alpha, delta and epsilon from studies of exonuclease and polymerase active site mutations

Relevant mutation

His+ reversion rate (× 10-8)

Fold increase

+/+

0.5

1

 

0.3–1.2

 

+/ pol2-Y831A

1.1

2.2

 

0.7–1.7

 

pol2-Y831A/ pol2-Y831A

2.2

4.4

 

1.8–5.7

 

+/pol2-4

3.8

7.6

 

2.6–4.7

 

pol2-4/pol2-4

26

52

 

16–45

 

pol2-4/ pol2-Y831A

28

56

 

16–53

 

pol2-4/ pol2-4,Y831A

21

42

 

18–34

 

pol2-Y831A/ pol2-4,Y831A

1.8

3.6

 

1.2–3.1

 

pol2-4,Y831A/pol2-4,Y831A

1.8

3.6

 

1.1–2.3

 
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BMC Biology

ISSN: 1741-7007

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