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Figure 3 | BMC Biology

Figure 3

From: Low dose pramipexole is neuroprotective in the MPTP mouse model of Parkinson's disease, and downregulates the dopamine transporter via the D3 receptor

Figure 3

Impact of pramipexole on MPTP-induced loss of DAT-IR fibers. Low-power photomicrograph (20x) of the caudate-putamen and nucleus accumbens of tissue sections processed for DAT-IR from individual cases of 4 groups of mice: (A) Saline-Saline, (B) pramipexole – Saline, (C) Saline -MPTP (20 mg/kg sc., 4 times in 2 days at 8 h intervals), (D) pramipexole-MPTP. Note the marked depletion of DAT-IR from the caudate-putamen (C) and apparent protection by pramipexole (D). Abbreviation: CPu, caudate-putamen; NAS, nucleus accumbens shell; NAC, nucleus accumbens core.

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