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Figure 6 | BMC Biology

Figure 6

From: Low dose pramipexole is neuroprotective in the MPTP mouse model of Parkinson's disease, and downregulates the dopamine transporter via the D3 receptor

Figure 6

Effects of pramipexole on the kinetics of [ 3 H]DA and [ 3 H]MPP+ uptake. Effects of subchronic treatment pramipexole or vehicle (saline) on [3H]DA uptake (A) and [3H]MPP+ uptake (B) in striatal synaptosomes from treated mice. Group data are plotted with the mean ± standard error of the mean from 6 samples per group. The dashed line for each of the means represents the calculated 95% confidence interval. The V max and K m were calculated for each group and paired comparisons by t-test revealed significant differences.

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