Effects of pramipexole on the kinetics of [
H]DA and [
H]MPP+ uptake. Effects of subchronic treatment pramipexole or vehicle (saline) on [3H]DA uptake (A) and [3H]MPP+ uptake (B) in striatal synaptosomes from treated mice. Group data are plotted with the mean ± standard error of the mean from 6 samples per group. The dashed line for each of the means represents the calculated 95% confidence interval. The V
max and K
m were calculated for each group and paired comparisons by t-test revealed significant differences.