Figure 7 From: Low dose pramipexole is neuroprotective in the MPTP mouse model of Parkinson's disease, and downregulates the dopamine transporter via the D3 receptor Effects of pramipexole on DAT density at 14 days post-treatment. Effects of subchronic treatment with pramipexole on density of [125I] RTI-55 labeled sites by autoradiography. Animals survived for 14 days after the last pramipexole injection. Data are mean ± standard deviation of the mean from 4–5 samples per group. * for P < 0.01, PPX-WT vs all groups. Abbreviations: CPU, caudate-putamen; Nac Core, nucleus accumbens core; Nac Shell, nucleus accumbens shell; PPX-KO, pramipexole treated D3 knockout mice; PPX-WT, pramipexole treated WT mice; SAL-KO, saline treated D3 knockout mice; SAL-WT, saline treated WT mice.Back to article page