Effects of pramipexole on DAT density at 14 days post-treatment. Effects of subchronic treatment with pramipexole on density of [125I] RTI-55 labeled sites by autoradiography. Animals survived for 14 days after the last pramipexole injection. Data are mean ± standard deviation of the mean from 4–5 samples per group. * for P < 0.01, PPX-WT vs all groups. Abbreviations: CPU, caudate-putamen; Nac Core, nucleus accumbens core; Nac Shell, nucleus accumbens shell; PPX-KO, pramipexole treated D3 knockout mice; PPX-WT, pramipexole treated WT mice; SAL-KO, saline treated D3 knockout mice; SAL-WT, saline treated WT mice.