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Figure 7 | BMC Biology

Figure 7

From: Low dose pramipexole is neuroprotective in the MPTP mouse model of Parkinson's disease, and downregulates the dopamine transporter via the D3 receptor

Figure 7

Effects of pramipexole on DAT density at 14 days post-treatment. Effects of subchronic treatment with pramipexole on density of [125I] RTI-55 labeled sites by autoradiography. Animals survived for 14 days after the last pramipexole injection. Data are mean ± standard deviation of the mean from 4–5 samples per group. * for P < 0.01, PPX-WT vs all groups. Abbreviations: CPU, caudate-putamen; Nac Core, nucleus accumbens core; Nac Shell, nucleus accumbens shell; PPX-KO, pramipexole treated D3 knockout mice; PPX-WT, pramipexole treated WT mice; SAL-KO, saline treated D3 knockout mice; SAL-WT, saline treated WT mice.

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