Low dose pramipexole is neuroprotective in the MPTP mouse model of Parkinson's disease, and downregulates the dopamine transporter via the D3 receptor

Table 1 Effects of genotype and drug on [³H]DA uptake and DAT density

Wild-type and D₃ KO mice were administered vehicle (0.9% saline) or pramipexole (PPX, 0.1 mg/kg I.P.) once a day for 5 days. Twenty-four hours after the last injection the brains were removed, the CPu dissected and fresh frozen ([³H]DA uptake) or brains frozen on dry-ice ([¹²⁵I] RTI-55 autoradiography).
[³H]DA uptake Vmax reported as pmol/mg P/5 min and Km reported as nM. [¹²⁵I] RTI-55 autoradiography for DAT density reported as fmol/μg P.

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