Skip to main content
Figure 1 | BMC Biology

Figure 1

From: Brief inactivation of c-Myc is not sufficient for sustained regression of c-Myc-induced tumours of pancreatic islets and skin epidermis

Figure 1

Histological comparison of pancreatic islets from pIns-c-MycER TAM / Bcl-x L transgenic mice following activation, inactivation and reactivation of c-MycER TAM (c-Myc). Paraffin-embedded fixed sections of pancreata from c-MycER TAM/Bcl-x L mice were examined histologically by H&E staining. In the absence of 4-OHT (inactive c-Myc) islets exhibited normal morphology (Normal). Activation of c-Myc for 14 days following daily IP injection with 4-OHT induced the formation of hyperplastic, angiogenic islets (c-Myc on). Islets following subsequent inactivation of c-Myc for 9 days by withdrawing 4-OHT show evidence of vasculature collapse (c-Myc on-off). Reactivation of c-Myc for 5 days in partially regressed islets restored the neoplastic phenotype (c-Myc on-off-on). Scale bar: 100 μm

Back to article page