Figure 3

Comparison of antibiotic binding sites. (A) To visualize the relative orientations of different classes of antibiotics and substrates compared with dalfopristin and quinupristin, several structures have been aligned and overlaid: clindamycin (PDB entry 1JZX), erythromycin (1JZY), chloramphenicol (1K01) and CC-Puromycin molecules in A- (A-CCPuro) and P-site (P-CCPuro). CC-Puromycin coordinates were taken from Bashan et al. (2003) [40]. (B) Overview of the binding sites of quinupristin and dalfopristin within the 50S ribosomal subunit, in relation to the P-site tRNA and the ribosomal exit tunnel (highlighted in gold).