The TyrA family of aromatic-pathway dehydrogenases in phylogenetic context

Table 1 Abbreviations used to designate substrate specificities of tyrA/TyrA homologs

Abbreviation^a
Gene	Gene Product	Description of specificity^b
tyrA _x	TyrA_x	Specificity for cyclohexadienyl substrate is unknown
tyrA _c	TyrA_c	Broad-specificity cyclohexadienyl dehydrogenase (CDH)
tyrA _p	TyrA_p	Narrow-specificity prephenate dehydrogenase (PDH)
TyrA_{c_Δ}	TyrA_{c_Δ}	Broad-specificity cyclohexadienyl dehydrogenase having catalytic-core indels in correlation with an extra-core extension
tyrA _a	TyrA_a	Narrow-specificity arogenate dehydrogenase (ADH)
_NAD tyrA _a	_NADTyrA_a	TyrA homolog is AGN-specific and NAD⁺-specific
_NADP tyrA _a	_NADPTyrA_a	TyrA homolog is AGN-specific and NADP⁺-specific
_NAD(P) tyrA _a	_NAD(P)TyrA_a	TyrA homolog is AGN-specific but utilizes either NAD⁺ or NADP⁺
_x tyrA _x	_xTyrA_x	Specificity for both the cyclohexadienyl and pyridine nucleotide substrates is unknown

^aAbbreviations in the upper-table (upper 5 rows) indicate the specificities for the cyclohexadienyl substrate. Abbreviations in the lower-table (lower 4 rows) indicate specificities for both cyclohexadienyl (right subscripts) and pyridine nucleotide substrates (left subscripts). Combinations not shown can be deduced from the examples given, e.g., a TyrA homolog specific for prephenate and NAD⁺ would be designated _NADTyrA_p.
^bThe abbreviations CDH, PDH, and ADH (shown parenthetically) have been used frequently in the literature.

ISSN: 1741-7007