The TyrA family of aromatic-pathway dehydrogenases in phylogenetic context

Table 4 Cyclohexadienyl substrates and inhibitors of TyrA proteins possess identical sidechains

Organism	Co-substrate	Substrate(s)	Inhibitor(s) ^a	Reference
Synechocystis sp.	NADP⁺	AGN	TYR	[25]
Arabidopsis thaliana	NADP⁺	AGN	TYR	[27, 28]
Nitrosomonas europaea	NADP⁺	AGN	None	[21]
Corynebacterium glutamicum	NAD(P)⁺	AGN	None	[42, 43]
Neisseria gonorrhoeae	NAD⁺	PPA^b	HPP	[21]
Pseudomonas stutzeri	NAD⁺	PPA/AGN	HPP/TYR	[1]
Pseudomonas aeruginosa	NAD⁺	PPA/AGN	HPP/TYR	[17]
Zymomonas mobilis	NAD⁺	PPA/AGN	None	[18]

^aAbbreviation: HPP, 4-hydroxyphenylpyruvate. ^bThis TyrA_c enzyme has an overwhelming preference for PPA, but will use AGN poorly.

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