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Figure 4 | BMC Biology

Figure 4

From: A mutation in the centriole-associated protein centrin causes genomic instability via increased chromosome loss in Chlamydomonas reinhardtii

Figure 4

Production of inviable progeny cells during division in haploid Chlamydomonas cells. Graph shows fraction of cell divisions in which one or both progeny cells are inviable based on morphology. (Green) Wild type; n = 97. (Red) The fla10 mutant, previously shown to have elevated rate of chromosome loss; n = 18. Production of inviable progeny likely reflects spontaneous missegregation of chromosomes resulting in nullisomic progeny that die due to lack of essential genes. (Blue) The vfl2 mutant; n = 312. As predicted from chromosome loss measurements, this mutant shows an elevated rate of inviable progeny. (Grey) Outcomes for vfl2 mutant cells with less than two, two, or greater than two centrioles, as judged by flagellar number (numbers of cell divisions scored: less than two centrioles, n = 105; two centrioles, n = 136; greater than two centrioles, n = 71). Cells with supernumerary centrioles do not show an elevated rate of dead progeny production compared to cells with two or fewer centrioles.

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