Figure 7

Alignment of NUP62 and FLJ20130. (A) Protein sequences of human, opossum and chicken Nup62 were aligned with the peptide encoded by cDNA FLJ20130. While most of the mammalian NUP62 genes do not contain introns, the chicken NUP62 gene and the human gene encoding FLJ20130 do. Exon boundaries in the latter two sequences are indicated with pipes (|), and the lack of introns is indicated at the respective positions by dashes (-). The positions of exon boundaries are additionally highlighted in yellow. The N terminus of chicken Nup62 is probably incomplete. (B) Dot-plot of human nucleotide sequences FLJ20130 (presumed ancestor of NUP62) and AL162061 (NUP62). Windowsize was 55 bp, and stringency was set to 60% sequence identity. Coding regions in the two cDNAs are indicated with blue bars, and ORF boundaries are linked to the dot-plot alignment. The alignment extends past the protein coding sequences. The terminal and coding exon of AL162061 starts at position bp 129 and comprises the assumed retroposon.