Figure 5
Wnt-5 and Fz-2 morphant embryos exhibit similar pancreatic islet defects at 24 hpf. In all panels, anterior is to the left and 24 hpf. .A-I, dorsal view; J-L, lateral view. (A, D, G, J) Wild-type embryos. (B, E, H, K) Fz-2 morphants. (C, F, I, L) Wnt-5 morphants. In situ hybridization analysis of (A, B, C) somatostatin, (D, E, F) glucagon, notice a hollow spot in the middle of each patch, (G, H, I) islet-1, (J, K, L) fspondin-2b. Note scattered pancreatic cells in Fz-2 and Wnt-5 morphants.