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Table 1 EC50 and Emax values for inhibition of cAMP accumulation by spiradoline

From: Engineered G protein coupled receptors reveal independent regulation of internalization, desensitization and acute signaling

  Rog Rog-A Rog-μ Rog-μA
  EC50 (nM spiradoline)
Acute activation 0.41 ± 0.08 0.41 ± 0.15 0.42 ± 0.23 0.50 ± 0.22
1 nM spiradoline pretreatment 4.32 ± 1.96 0.42 ± 0.21 2.05 ± 0.03 > 13.44 ± 5.41
  % Inhibition
Acute activation 64.4 ± 4.8 56.1 ± 5.1 58.0 ± 0.9 64.1 ± 4.8
1 nM spiradoline pretreatment 55.7 ± 3.7 53.3 ± 0.9 43.6 ± 1.5 51.5 ± 6.0
  1. Values are mean ± SEM for 3–8 experiments for each condition.