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Figure 3 | BMC Biology

Figure 3

From: Genetic context determines susceptibility to intraocular pressure elevation in a mouse pigmentary glaucoma

Figure 3

Tyrosinase deficiency prevents iris disease in B6. Tyrp1 b Gpnmb R150X mice. Intercrosses generated mice homozygous for various genotypic combinations of the Tyrp1 band Gpnmb R150Xmutations with the albino-inducing Tyr c-2Jmutation. These mice were aged and analyzed by slit-lamp examination; representative B6.Tyrp1 b Gpnmb R150Xeyes are shown. (A) The normally brown pigmented coat of a mouse on the left compared with a triple homozygous Tyr c-2J Tyrp1 b Gpnmb R150Xmouse on the right. (B, D, F) Different views emphasize the clinical morphology of the albino iris. Eyes of B6 mice that are homozygous for the Tyr c-2Jmutation only appear pink as they lack melanin, but otherwise the iris and its vasculature have normal morphology. (C, E, G) Homozygosity for Tyr c-2Jcompletely prevents iris disease in B6.Tyrp1 b Gpnmb R150X Tyr c-2Jmice. The iris morphology of the triple mutant is indistinguishable from that of B6 mice homozygous for Tyr c-2Jonly (compare 3B to 3C), lacks peripupillary abnormalities (compare 3D to 3E), and has a healthy uninterrupted vasculature (3F to 3G). n = 14 eyes, all 12+ months.

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