TY - JOUR AU - Leiper, Lucy J. AU - Walczysko, Petr AU - Kucerova, Romana AU - Ou, Jingxing AU - Shanley, Lynne J. AU - Lawson, Diane AU - Forrester, John V. AU - McCaig, Colin D. AU - Zhao, Min AU - Collinson, J. Martin PY - 2006 DA - 2006/08/16 TI - The roles of calcium signaling and ERK1/2 phosphorylation in a Pax6+/-mouse model of epithelial wound-healing delay JO - BMC Biology SP - 27 VL - 4 IS - 1 AB - Congenital aniridia caused by heterozygousity at the PAX6 locus is associated with ocular surface disease including keratopathy. It is not clear whether the keratopathy is a direct result of reduced PAX6 gene dosage in the cornea itself, or due to recurrent corneal trauma secondary to defects such as dry eye caused by loss of PAX6 in other tissues. We investigated the hypothesis that reducing Pax6 gene dosage leads to corneal wound-healing defects. and assayed the immediate molecular responses to wounding in wild-type and mutant corneal epithelial cells. SN - 1741-7007 UR - https://doi.org/10.1186/1741-7007-4-27 DO - 10.1186/1741-7007-4-27 ID - Leiper2006 ER -