EGF addition corrects the wound response in mutants. (A)Priming Pax6
+/- cultures 90 s prior to wounding with 10 ng/ml EGF induced a significantly more intense Ca2+ wave that was comparable to Pax6
+/+ cultures (p = 0.667). (B) The initial rate of healing in EGF-treated Pax6
+/- cultures was restored to wild-type levels, and significantly higher than in control Pax6
+/- cultures (*, p < 0.001).