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Table 1 Calcium response, genotype and wound healing.

From: The roles of calcium signaling and ERK1/2 phosphorylation in a Pax6 +/-mouse model of epithelial wound-healing delay

  High [Ca]i Healing
  Initiation Propagation 0–2 h 2–6 h
Pax6 +/+ +++ +++ +++ +++
No Ca2+ o - + - -
No Ca2+ i +++ - - -
No P2Y +++ - - -
+ ATP +++ +++ +++ +++
Pax6 +/- +++ + - +++
Pax6 +/- + ATP +++ + - +++
Pax6 +/- + EGF +++ +++ +++ +++
  1. +++, normal wild-type control response; +, subnormal response; -, response not detectable.