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Table 2 Summary of single marker association analyses with BSE status

From: A major genetic component of BSE susceptibility

 

Frequency of Deletion

P-Valuec

Logistic Regression Analysis

23-bp indel

Casesa

(n)

Controlsa

(n)

 

P-Valued

OR ins/dele

OR del/dele

PARf

UK Holstein

75.9

(363)

70.8

(276)

4.2 × 10-2

2.9 × 10-2

1.36

1.84

0.24

German Holstein

68.9

(127)

61.8b

(335)

4.3 × 10-2

4.4 × 10-2

1.38

1.91

0.46

German Brown

53.5

(43)

34.5

(87)

3.3 × 10-3

5.4 × 10-3

4.74

4.62

0.69

German Fleckvieh

73.6

(106)

68.0

(136)

1.8 × 10-1

1.9 × 10-1

1.31

1.71

0.36

Combined

 

(639)

 

(834)

2.0 × 10-3 g

5.7 × 10-5

1.43

2.04

 

12-bp indel

         

UK Holstein

72.1

(350)

63.0

(270)

5.8 × 10-4

3.2 × 10-4

1.61

2.60

0.53

German Holstein

62.8

(125)

53.2b

(357)

9.1 × 10-3

1.1 × 10-2

1.48

2.20

0.35

German Brown

32.6

(43)

14.4

(90)

5.9 × 10-4

1.1 × 10-2

4.01

3.65

0.44

German Fleckvieh

68.4

(106)

62.0

(137)

1.5 × 10-1

1.5 × 10-1

1.32

1.74

0.44

Combined

 

(624)

 

(854)

8.7 × 10-5 g

1.2 × 10-7

1.58

2.50

 
  1. a Represents frequency (%) of deletion allele as calculated from genotypes; (n) indicates the number of individuals.
  2. b Control consists of half-sibs (see Additional File 1: Inferring allele, genotype, haplotype and diplotype frequencies from half-sibs).
  3. c P-values of χ2-test.
  4. d P-values from logistic regression, modelling the number of deletion alleles on BSE status.
  5. e Odds Ratios with reference genotype: ins/ins.
  6. f Population Attributable Risk: the portion of the BSE incidence in the population that is due to 12-bp deletion allele [15, 16].
  7. g P-Values of Fisher's Combined Probability test.
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