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Table 4 Summary of diplotype association analyses with BSE status

From: A major genetic component of BSE susceptibility

 

No. of 12-bp Deletion

Frequency of Diplotypes

  

UK Holstein

 

Casesa

(n)

Controlsa

(n)

P-Valued

ORe

23del-12ins/23del-12ins

0

0

(0)

<1.0

(3)

-

 

23ins-12ins/23ins-12insc

0

3.7

(13)

4.8

(13)

4.8 × 10-1

1c

23del-12ins/23ins-12ins

0

1.7

(6)

5.1

(14)

1.4 × 10-2

0.45

23del-12ins/23del-12del

1

6.5

(23)

8.8

(24)

2.7 × 10-1

0.96

23ins-12ins/23del-12del

1

39.0

(139)

43.6

(119)

2.4 × 10-1

1.17

23del-12del/23del-12del

2

48.7

(172)

36.6

(100)

3.6 × 10-3

1.72

German Holstein

       

23del-12ins/23del-12ins

0

<1.0

(1)

<1.0

(3)b

-

 

23ins-12ins/23ins-12insc

0

7.8

(10)

15.3

(47)b

6.1 × 10-2

1c

23del-12ins/23ins-12ins

0

5.5

(7)

7.1

(22)b

6.0 × 10-1

1.48

23del-12ins/23del-12del

1

6.3

(8)

9.4

(29)b

2.4 × 10-1

1.18

23ins-12ins/23del-12del

1

39.1

(50)

40.6

(125)b

3.4 × 10-2

1.73

23del-12del/23del-12del

2

40.6

(52)

26.6

(82)b

1.2 × 10-2

2.54

German Brown

       

23del-12ins/23del-12ins

0

2.4

(1)

3.3

(3)

-

 

23ins-12ins/23ins-12insc

0

14.3

(6)

45.6

(41)

3.7 × 10-4

1c

23del-12ins/23ins-12ins

0

26.2

(11)

25.6

(23)

9.6 × 10-1

3.12

23del-12ins/23del-12del

1

11.9

(5)

6.7

(6)

3.1 × 10-1

5.40

23ins-12ins/23del-12del

1

38.1

(16)

15.6

(14)

4.3 × 10-3

7.27

23del-12del/23del-12del

2

7.1

(3)

3.3

(3)

-

6.38

German Fleckvieh

       

23del-12ins/23del-12ins

0

<1.0

(1)

0

(0)

-

 

23ins-12ins/23ins-12insc

0

6.5

(7)

10.9

(15)

2.4 × 10-1

1c

23del-12ins/23ins-12ins

0

1.9

(2)

4.3

(6)

-

0.79

23del-12ins/23del-12del

1

6.5

(7)

6.5

(9)

1

1.63

23ins-12ins/23del-12del

1

38.9

(42)

39.1

(54)

1

1.61

23del-12del/23del-12del

2

45.4

(49)

39.1

(54)

2.9 × 10-1

1.88

Combined

       

23del-12ins/23del-12ins

0

      

23ins-12ins/23ins-12insc

0

     

1c

23del-12ins/23ins-12ins

0

     

1.22

23del-12ins/23del-12del

1

     

1.70

23ins-12ins/23del-12del

1

     

2.10

23del-12del/23del-12del

2

     

2.86

  1. a Represents the frequency (%) of diplotypes; (n) indicates the number of individuals.
  2. b Calculated assuming Hardy-Weinberg equilibrium from haplotype frequency estimates (see Additional File 1: Inferring allele, genotype, haplotype and diplotype frequencies from half-sibs).
  3. c Diplotype taken as reference.
  4. d P-values from χ2-test against pooled observations of all remaining diplotypes.
  5. eOdds Ratios from logistic regression.
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BMC Biology

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