G-CSF reduces cortical and subcortical infarct volume in the rat MCAO model when applied 4 h after onset of ischemia. A. Shown are infarct volumes for the total infarct, cortical and subcortical areas. Infarct volumes were determined 24 h after onset of ischemia by TTC-staining and planimetry. B. Infarct volumes after edema correction. Edema-corrected infarct volumes were obtained by deducting the non-infarcted ipsilateral hemisphere volume from the contralateral hemisphere volume. Volumes are given in mm3 as means ± SEM.