Figure 2

G-CSF improves functional outcome when given as late as 72 h after photothrombotic ischemia. A. Design of the cortical photothrombotic experiment. B. Rotarod performance over the course of 6 weeks after ischemia. Rats received 10 μg/kg bodyweight/day G-CSF for 10 days starting either at 24 or 72 h after ischemia. The effect is also detectable by an analysis of individual areas-under-the-curve (AUC). (*,#: p < 0.05 by ANOVA and Student-Newman-Keuls post-hoc test for 24 h (#) and 72 h (*) treatment). C. Linear regression analysis of vehicle treatment and G-CSF treatment initiated at 72 h demonstrates that slopes are significantly different by a factor of 2 (p = 0.004)