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Table 2 Proteins with maximal degree-rank. The rank of a protein in the list of proteins ordered by degree, gene name, and number of connections of the top-ten most connected proteins in the full network are listed, followed by their corresponding mean rankings from the ensemble of 1000 20%, 40%, 60% and 80% subnetworks. Value in brackets are the number of subnets (out of 1000) in which the protein was present. The final column shows the degree in the high-confidence DIP data set; the correspondence between the degrees of a protein in both datasets appears to be poor. Overall, however, there is significant correlation between a protein's degree in the two data sets (τ ≈ 0.53).

From: The effects of incomplete protein interaction data on structural and evolutionary inferences

Rank Network

Gene

Degree Network

Avg. rank 20% subnet

Avg. rank 40% subnet

Avg. rank 60% subnet

Avg. rank 80% subnet

Degree in high confidence data

1

JSN1

283

1 (206)

1 (394)

1 (599)

1 (811)

–

2

CDC28

213

1.3 (193)

1.5 (416)

1.7 (585)

1.9 (797)

4

3

SRP1

197

1.3 (188)

1.7 (395)

2.1 (595)

2.5 (796)

11

4

NUP116

147

1.7 (182)

2.4 (383)

2.8 (591)

3.4 (809)

2

5

ATP14

125

2.1 (176)

2.9 (386)

3.7 (603)

4.4 (796)

–

6

SUA7

115

2.2 (193)

3.4 (414)

4.5 (616)

5.6 (806)

8

7

TEM1N

115

2.4 (183)

3.5 (402)

4.6 (597)

5.7 (791)

–

8

SRB4

109

2.6 (192)

3.8 (390)

5.2 (580)

6.7 (799)

4

9

BZZ1

107

2.6 (195)

3 (401)

5.3 (593)

6.9 (815)

1

10

VMA6

95

3.7 (193)

4.6 (414)

6.6 (582)

8.6 (788)

2