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Figure 5 | BMC Biology

Figure 5

From: Nucleus accumbens corticotropin-releasing factor increases cue-triggered motivation for sucrose reward: paradoxical positive incentive effects in stress?

Figure 5

Response competition between sucrose dish approach and lever pressing. A. Averaged time-course of approach responses to sucrose dish just before, during and after first CS+ cue presentation. B. Same information for pressing on sucrose-associated lever. Each panel compares cue-triggered responding after microinjections of vehicle (white circles), CRF 500 Ī¼g (green circles), CRF 250 Ī¼g (blue circles), or amphetamine 20 Ī¼g (red circles). Both CRF and amphetamine reduced the peak of cue-triggered approaches to the sucrose dish, but simultaneously increased cue-triggered lever pressing. It is impossible to perform both actions at exactly the same time, and so conditioned dish approaches may have been suppressed as a result of response competition from increased lever pressing that occurred during the same 30-sec period.

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