Corto and DSP1 interact and bind to a maintenance element of the Scr Hox gene: understanding the role of Enhancers of trithorax and Polycomb

Table 1 Genetic interactions between dsp1 and corto

Genotype	Legs observed	average sex comb teeth on the T1 leg	Males observed	A6 to A5 (%)
+/Y	52	11.1	36	0
dsp1 ¹/Y ; +/+	40	6.0	46	25
+/Y; corto ⁴²⁰/+	61	10.5	37	0
+/Y; corto ⁰⁷¹²⁸/+	48	11.2	34	0
dsp1 ¹/Y; corto ⁴²⁰/+	113	9.0	68	0
dsp1 ¹/Y; corto ⁰⁷¹²⁸/+	31	9.0	69	3

Homozygous dsp1 ¹females were crossed with either corto ⁴²⁰/TM3 or corto ⁰⁷¹²⁸/TM3 males, or with Oregon-R males as controls. The resulting male progeny was scored for two homeotic transformations previously observed in dsp1 ¹ mutants: (i) transformation of T1 leg into T2 leg monitored by the size of the sex comb, (ii) transformation of segment A6 into segment A5 as revealed by the presence of bristles on A6 sternites.

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