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Table 5 Tests of neutrality in SDHA

From: Sequence variation in human succinate dehydrogenase genes: evidence for long-term balancing selection on SDHA

Locus Length (bp) Population Sample size (n)* S† % θs % π Tajima D test statistic Fu and Li D* test statistic Fu and Li F* test statistic
Coding 1995 AA 23 14 0.16 0.238 1.515 (0.053) -0.352 (0.428) 0.320 (0.367)
  1995 EA 22 10 0.115 0.147 0.797 (0.181) 0.805 (0.098) 0.945 (0.154)
  1995 All 45 15 0.148 0.204 1.046 (0.116) -1.065 (0.210) -0.361 (0.361)
Synonymous 1995 AA 23 11 0.125 0.191 1.542 (0.051) -0.249 (0.491) 0.399 (0.344)
  1995 EA 22 8 0.092 0.116 0.726 (0.192) 0.612 (0.416) 0.761 (0.215)
  1995 All 45 12 0.119 0.163 1.003 (0.132) -0.988 (0.235) -0.339 (0.383)
Non-synonymous 1995 AA 23 3 0.034 0.047 0.810 (0.197) -0.390 (0.449) -0.036 (0.495)
  1995 EA 22 2 0.023 0.031 0.597 (0.231) 0.761 (0.428) 0.827 (0.236)
  1995 All 45 3 0.03 0.041 0.687 (0.215) -0.561 (0.499) -0.199 (0.453)
Non-coding 3275 AA 23 19 0.133 0.217 2.046 (0.015) 0.908 (0.084) 1.534 (0.036)
  3275 EA 22 15 0.106 0.145 1.176 (0.092) 1.565 (0.038) 1.696 (0.020)
  3275 All 45 19 0.115 0.195 2.020 (0.019) 1.707 (0.025) 2.174 (0.005)
Coding and non-coding 5255 AA 23 33 0.143 0.225 1.954 (0.017) 0.402 (0.279) 1.128 (0.091)
  5255 EA 22 25 0.11 0.17 1.114 (0.106) 1.452 (0.037) 1.584 (0.029)
  5255 All 45 34 0.128 0.198 1.721 (0.036) 0.521 (0.228) 1.183 (0.079)
  1. AA, African American samples; EA, European American samples; SD, standard deviation.
  2. Significant p values (within parentheses) are in bold.
  3. *Number of unrelated subjects.
  4. †Number of segregating sites. DnaSp software excludes from the analyses the insertion/deletion variants, two of which were detected in the non-coding SDHA sequence. Inclusion of the SDHA indels, by recoding them as SNPs, increased all SDHA test statistics and reduced the p values (data not shown)