Sequence variation in human succinate dehydrogenase genes: evidence for long-term balancing selection on SDHA

Table 5 Tests of neutrality in SDHA

Locus	Length (bp)	Population	Sample size (n)*	S†	% θ_s	% π	Tajima D test statistic	Fu and Li D* test statistic	Fu and Li F* test statistic
Coding	1995	AA	23	14	0.16	0.238	1.515 (0.053)	-0.352 (0.428)	0.320 (0.367)
	1995	EA	22	10	0.115	0.147	0.797 (0.181)	0.805 (0.098)	0.945 (0.154)
	1995	All	45	15	0.148	0.204	1.046 (0.116)	-1.065 (0.210)	-0.361 (0.361)
Synonymous	1995	AA	23	11	0.125	0.191	1.542 (0.051)	-0.249 (0.491)	0.399 (0.344)
	1995	EA	22	8	0.092	0.116	0.726 (0.192)	0.612 (0.416)	0.761 (0.215)
	1995	All	45	12	0.119	0.163	1.003 (0.132)	-0.988 (0.235)	-0.339 (0.383)
Non-synonymous	1995	AA	23	3	0.034	0.047	0.810 (0.197)	-0.390 (0.449)	-0.036 (0.495)
	1995	EA	22	2	0.023	0.031	0.597 (0.231)	0.761 (0.428)	0.827 (0.236)
	1995	All	45	3	0.03	0.041	0.687 (0.215)	-0.561 (0.499)	-0.199 (0.453)
Non-coding	3275	AA	23	19	0.133	0.217	2.046 (0.015)	0.908 (0.084)	1.534 (0.036)
	3275	EA	22	15	0.106	0.145	1.176 (0.092)	1.565 (0.038)	1.696 (0.020)
	3275	All	45	19	0.115	0.195	2.020 (0.019)	1.707 (0.025)	2.174 (0.005)
Coding and non-coding	5255	AA	23	33	0.143	0.225	1.954 (0.017)	0.402 (0.279)	1.128 (0.091)
	5255	EA	22	25	0.11	0.17	1.114 (0.106)	1.452 (0.037)	1.584 (0.029)
	5255	All	45	34	0.128	0.198	1.721 (0.036)	0.521 (0.228)	1.183 (0.079)

AA, African American samples; EA, European American samples; SD, standard deviation.
Significant p values (within parentheses) are in bold.
*Number of unrelated subjects.
†Number of segregating sites. DnaSp software excludes from the analyses the insertion/deletion variants, two of which were detected in the non-coding SDHA sequence. Inclusion of the SDHA indels, by recoding them as SNPs, increased all SDHA test statistics and reduced the p values (data not shown)

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