Locus
|
Length (bp)
|
Population
|
Sample size (n)*
|
S†
|
% θs
|
% π
|
Tajima D test statistic
|
Fu and Li D* test statistic
|
Fu and Li F* test statistic
|
---|
Coding
|
1995
|
AA
|
23
|
14
|
0.16
|
0.238
|
1.515 (0.053)
|
-0.352 (0.428)
|
0.320 (0.367)
|
|
1995
|
EA
|
22
|
10
|
0.115
|
0.147
|
0.797 (0.181)
|
0.805 (0.098)
|
0.945 (0.154)
|
|
1995
|
All
|
45
|
15
|
0.148
|
0.204
|
1.046 (0.116)
|
-1.065 (0.210)
|
-0.361 (0.361)
|
Synonymous
|
1995
|
AA
|
23
|
11
|
0.125
|
0.191
|
1.542 (0.051)
|
-0.249 (0.491)
|
0.399 (0.344)
|
|
1995
|
EA
|
22
|
8
|
0.092
|
0.116
|
0.726 (0.192)
|
0.612 (0.416)
|
0.761 (0.215)
|
|
1995
|
All
|
45
|
12
|
0.119
|
0.163
|
1.003 (0.132)
|
-0.988 (0.235)
|
-0.339 (0.383)
|
Non-synonymous
|
1995
|
AA
|
23
|
3
|
0.034
|
0.047
|
0.810 (0.197)
|
-0.390 (0.449)
|
-0.036 (0.495)
|
|
1995
|
EA
|
22
|
2
|
0.023
|
0.031
|
0.597 (0.231)
|
0.761 (0.428)
|
0.827 (0.236)
|
|
1995
|
All
|
45
|
3
|
0.03
|
0.041
|
0.687 (0.215)
|
-0.561 (0.499)
|
-0.199 (0.453)
|
Non-coding
|
3275
|
AA
|
23
|
19
|
0.133
|
0.217
|
2.046 (0.015)
|
0.908 (0.084)
|
1.534 (0.036)
|
|
3275
|
EA
|
22
|
15
|
0.106
|
0.145
|
1.176 (0.092)
|
1.565 (0.038)
|
1.696 (0.020)
|
|
3275
|
All
|
45
|
19
|
0.115
|
0.195
|
2.020 (0.019)
|
1.707 (0.025)
|
2.174 (0.005)
|
Coding and non-coding
|
5255
|
AA
|
23
|
33
|
0.143
|
0.225
|
1.954 (0.017)
|
0.402 (0.279)
|
1.128 (0.091)
|
|
5255
|
EA
|
22
|
25
|
0.11
|
0.17
|
1.114 (0.106)
|
1.452 (0.037)
|
1.584 (0.029)
|
|
5255
|
All
|
45
|
34
|
0.128
|
0.198
|
1.721 (0.036)
|
0.521 (0.228)
|
1.183 (0.079)
|
- AA, African American samples; EA, European American samples; SD, standard deviation.
- Significant p values (within parentheses) are in bold.
- *Number of unrelated subjects.
- †Number of segregating sites. DnaSp software excludes from the analyses the insertion/deletion variants, two of which were detected in the non-coding SDHA sequence. Inclusion of the SDHA indels, by recoding them as SNPs, increased all SDHA test statistics and reduced the p values (data not shown)