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Table 2 Neutral evolution robustness and mutation data. Each row represents a different generation, T. NA indicates that no measurement was made. The 〈m nt 〉 and 〈m aa 〉 are the average number of nucleotide mutations and nonsynonymous mutations, respectively. Numbers in parentheses are total counts over the total samples. Subscripts indicate the population type: U for unselected, P for polymorphic, and M for monomorphic. For the unselected and monomorphic populations, numbers represent averages of all replicates. For the polymorphic population, numbers are for a random sample of functional mutants. 〈 MathType@MTEF@5@5@+=feaafiart1ev1aaatCvAUfKttLearuWrP9MDH5MBPbIqV92AaeXatLxBI9gBaebbnrfifHhDYfgasaacH8akY=wiFfYdH8Gipec8Eeeu0xXdbba9frFj0=OqFfea0dXdd9vqai=hGuQ8kuc9pgc9s8qqaq=dirpe0xb9q8qiLsFr0=vr0=vr0dc8meaabaqaciaacaGaaeqabaqabeGadaaakeaat0uy0HwzTfgDPnwy1egaryqtHrhAL1wy0L2yHvdaiqaacqWFXeIraaa@3786@ P and 〈 MathType@MTEF@5@5@+=feaafiart1ev1aaatCvAUfKttLearuWrP9MDH5MBPbIqV92AaeXatLxBI9gBaebbnrfifHhDYfgasaacH8akY=wiFfYdH8Gipec8Eeeu0xXdbba9frFj0=OqFfea0dXdd9vqai=hGuQ8kuc9pgc9s8qqaq=dirpe0xb9q8qiLsFr0=vr0=vr0dc8meaabaqaciaacaGaaeqabaqabeGadaaakeaat0uy0HwzTfgDPnwy1egaryqtHrhAL1wy0L2yHvdaiqaacqWFXeIraaa@3786@ M are the fraction of functional mutants out of 435 assayed.

From: Evolution favors protein mutational robustness in sufficiently large populations

T m nt U m aa U m nt P m aa P m nt M m aa M MathType@MTEF@5@5@+=feaafiart1ev1aaatCvAUfKttLearuWrP9MDH5MBPbIqV92AaeXatLxBI9gBaebbnrfifHhDYfgasaacH8akY=wiFfYdH8Gipec8Eeeu0xXdbba9frFj0=OqFfea0dXdd9vqai=hGuQ8kuc9pgc9s8qqaq=dirpe0xb9q8qiLsFr0=vr0=vr0dc8meaabaqaciaacaGaaeqabaqabeGadaaakeaat0uy0HwzTfgDPnwy1egaryqtHrhAL1wy0L2yHvdaiqaacqWFXeIraaa@3786@ P MathType@MTEF@5@5@+=feaafiart1ev1aaatCvAUfKttLearuWrP9MDH5MBPbIqV92AaeXatLxBI9gBaebbnrfifHhDYfgasaacH8akY=wiFfYdH8Gipec8Eeeu0xXdbba9frFj0=OqFfea0dXdd9vqai=hGuQ8kuc9pgc9s8qqaq=dirpe0xb9q8qiLsFr0=vr0=vr0dc8meaabaqaciaacaGaaeqabaqabeGadaaakeaat0uy0HwzTfgDPnwy1egaryqtHrhAL1wy0L2yHvdaiqaacqWFXeIraaa@3786@ M
0 0 0 0 0 0 0 0.48 (210/435) 0.48 (210/435)
1 NA NA NA NA 0.1 (3/22) 0.3 (6/22) 0.48 (208/435) NA
2 NA NA NA NA 0.4 (9/22) 0.8 (17/22) 0.49 (215/435) NA
3 5.0 (20/4) 3.5 (14/4) 2.7 (27/10) 1.4 (14/10) 1.0 (23/22) 0.4 (9/22) 0.49 (215/435) NA
4 NA NA NA NA 1.5 (32/22) 0.7 (15/22) 0.48 (208/435) NA
5 NA NA NA NA 2.2 (48/22) 1.1 (25/22) 0.45 (197/435) 0.43 (185/435)
6 9.8 (39/4) 7.5 (30/4) 5.5 (55/10) 2.1 (21/10) 2.6 (58/22) 1.4 (31/22) 0.46 (198/435) NA
7 NA NA NA NA 3.1 (69/22) 1.8 (39/22) 0.52 (227/435) NA
8 NA NA NA NA 3.4 (74/22) 1.8 (40/22) 0.46 (200/435) NA
9 13.0 (52/4) 10.3 (41/4) 6.7 (61/9) 3.1 (28/9) 3.7 (82/22) 2.1 (46/22) 0.47 (203/435) NA
10 NA NA NA NA 4.2 (92/22) 2.4 (52/22) 0.46 (199/435) 0.40 (175/435)
11 NA NA NA NA 4.6 (102/22) 2.5 (56/22) 0.48 (207/435) NA
12 16.8 (67/4) 12.5 (50/4) 7.8 (70/9) 3.3 (30/9) 4.9 (107/22) 2.6 (58/22) 0.52 (228/435) NA
13 NA NA NA NA 5.0 (110/22) 2.7 (60/22) 0.52 (227/435) NA
14 NA NA NA NA 5.3 (116/22) 2.9 (64/22) 0.50 (216/435) NA
15 NA NA 10.3 (227/22) 3.8 (83/22) 5.6 (123/22) 3.0 (67/22) 0.50 (219/435) 0.39 (171/435)
16 NA NA NA NA 5.8 (127/22) 3.0 (67/22) NA NA
17 NA NA NA NA 6.0 (133/22) 3.1 (69/22) NA NA
18 NA NA NA NA 6.3 (137/22) 3.2 (71/22) NA NA
19 NA NA NA NA 6.3 (138/22) 3.3 (72/22) NA NA
20 NA NA NA NA 6.6 (145/22) 3.4 (75/22) NA 0.37 (160/435)
21 NA NA NA NA 6.9 (152/22) 3.6 (79/22) NA NA
22 NA NA NA NA 7.1 (156/22) 3.7 (81/22) NA NA
23 NA NA NA NA 7.2 (158/22) 3.7 (81/22) NA NA
24 NA NA NA NA 7.3 (161/22) 3.8 (83/22) NA NA
25 NA NA NA NA 7.7 (169/22) 4.0 (87/22) NA 0.39 (169/435)