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Table 2 Neutral evolution robustness and mutation data. Each row represents a different generation, T. NA indicates that no measurement was made. The 〈m nt 〉 and 〈m aa 〉 are the average number of nucleotide mutations and nonsynonymous mutations, respectively. Numbers in parentheses are total counts over the total samples. Subscripts indicate the population type: U for unselected, P for polymorphic, and M for monomorphic. For the unselected and monomorphic populations, numbers represent averages of all replicates. For the polymorphic population, numbers are for a random sample of functional mutants. 〈 ℱ MathType@MTEF@5@5@+=feaafiart1ev1aaatCvAUfKttLearuWrP9MDH5MBPbIqV92AaeXatLxBI9gBaebbnrfifHhDYfgasaacH8akY=wiFfYdH8Gipec8Eeeu0xXdbba9frFj0=OqFfea0dXdd9vqai=hGuQ8kuc9pgc9s8qqaq=dirpe0xb9q8qiLsFr0=vr0=vr0dc8meaabaqaciaacaGaaeqabaqabeGadaaakeaat0uy0HwzTfgDPnwy1egaryqtHrhAL1wy0L2yHvdaiqaacqWFXeIraaa@3786@ 〉 P and 〈 ℱ MathType@MTEF@5@5@+=feaafiart1ev1aaatCvAUfKttLearuWrP9MDH5MBPbIqV92AaeXatLxBI9gBaebbnrfifHhDYfgasaacH8akY=wiFfYdH8Gipec8Eeeu0xXdbba9frFj0=OqFfea0dXdd9vqai=hGuQ8kuc9pgc9s8qqaq=dirpe0xb9q8qiLsFr0=vr0=vr0dc8meaabaqaciaacaGaaeqabaqabeGadaaakeaat0uy0HwzTfgDPnwy1egaryqtHrhAL1wy0L2yHvdaiqaacqWFXeIraaa@3786@ 〉 M are the fraction of functional mutants out of 435 assayed.

From: Evolution favors protein mutational robustness in sufficiently large populations

T

〈m nt 〉 U

〈m aa 〉 U

〈m nt 〉 P

〈m aa 〉 P

〈m nt 〉 M

〈m aa 〉 M

〈 ℱ MathType@MTEF@5@5@+=feaafiart1ev1aaatCvAUfKttLearuWrP9MDH5MBPbIqV92AaeXatLxBI9gBaebbnrfifHhDYfgasaacH8akY=wiFfYdH8Gipec8Eeeu0xXdbba9frFj0=OqFfea0dXdd9vqai=hGuQ8kuc9pgc9s8qqaq=dirpe0xb9q8qiLsFr0=vr0=vr0dc8meaabaqaciaacaGaaeqabaqabeGadaaakeaat0uy0HwzTfgDPnwy1egaryqtHrhAL1wy0L2yHvdaiqaacqWFXeIraaa@3786@ 〉 P

〈 ℱ MathType@MTEF@5@5@+=feaafiart1ev1aaatCvAUfKttLearuWrP9MDH5MBPbIqV92AaeXatLxBI9gBaebbnrfifHhDYfgasaacH8akY=wiFfYdH8Gipec8Eeeu0xXdbba9frFj0=OqFfea0dXdd9vqai=hGuQ8kuc9pgc9s8qqaq=dirpe0xb9q8qiLsFr0=vr0=vr0dc8meaabaqaciaacaGaaeqabaqabeGadaaakeaat0uy0HwzTfgDPnwy1egaryqtHrhAL1wy0L2yHvdaiqaacqWFXeIraaa@3786@ 〉 M

0

0

0

0

0

0

0

0.48 (210/435)

0.48 (210/435)

1

NA

NA

NA

NA

0.1 (3/22)

0.3 (6/22)

0.48 (208/435)

NA

2

NA

NA

NA

NA

0.4 (9/22)

0.8 (17/22)

0.49 (215/435)

NA

3

5.0 (20/4)

3.5 (14/4)

2.7 (27/10)

1.4 (14/10)

1.0 (23/22)

0.4 (9/22)

0.49 (215/435)

NA

4

NA

NA

NA

NA

1.5 (32/22)

0.7 (15/22)

0.48 (208/435)

NA

5

NA

NA

NA

NA

2.2 (48/22)

1.1 (25/22)

0.45 (197/435)

0.43 (185/435)

6

9.8 (39/4)

7.5 (30/4)

5.5 (55/10)

2.1 (21/10)

2.6 (58/22)

1.4 (31/22)

0.46 (198/435)

NA

7

NA

NA

NA

NA

3.1 (69/22)

1.8 (39/22)

0.52 (227/435)

NA

8

NA

NA

NA

NA

3.4 (74/22)

1.8 (40/22)

0.46 (200/435)

NA

9

13.0 (52/4)

10.3 (41/4)

6.7 (61/9)

3.1 (28/9)

3.7 (82/22)

2.1 (46/22)

0.47 (203/435)

NA

10

NA

NA

NA

NA

4.2 (92/22)

2.4 (52/22)

0.46 (199/435)

0.40 (175/435)

11

NA

NA

NA

NA

4.6 (102/22)

2.5 (56/22)

0.48 (207/435)

NA

12

16.8 (67/4)

12.5 (50/4)

7.8 (70/9)

3.3 (30/9)

4.9 (107/22)

2.6 (58/22)

0.52 (228/435)

NA

13

NA

NA

NA

NA

5.0 (110/22)

2.7 (60/22)

0.52 (227/435)

NA

14

NA

NA

NA

NA

5.3 (116/22)

2.9 (64/22)

0.50 (216/435)

NA

15

NA

NA

10.3 (227/22)

3.8 (83/22)

5.6 (123/22)

3.0 (67/22)

0.50 (219/435)

0.39 (171/435)

16

NA

NA

NA

NA

5.8 (127/22)

3.0 (67/22)

NA

NA

17

NA

NA

NA

NA

6.0 (133/22)

3.1 (69/22)

NA

NA

18

NA

NA

NA

NA

6.3 (137/22)

3.2 (71/22)

NA

NA

19

NA

NA

NA

NA

6.3 (138/22)

3.3 (72/22)

NA

NA

20

NA

NA

NA

NA

6.6 (145/22)

3.4 (75/22)

NA

0.37 (160/435)

21

NA

NA

NA

NA

6.9 (152/22)

3.6 (79/22)

NA

NA

22

NA

NA

NA

NA

7.1 (156/22)

3.7 (81/22)

NA

NA

23

NA

NA

NA

NA

7.2 (158/22)

3.7 (81/22)

NA

NA

24

NA

NA

NA

NA

7.3 (161/22)

3.8 (83/22)

NA

NA

25

NA

NA

NA

NA

7.7 (169/22)

4.0 (87/22)

NA

0.39 (169/435)