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Table 1 uORF homology groups and associated mORF molecular function and biological role

From: Identification of novel conserved peptide uORF homology groups in Arabidopsis and rice reveals ancient eukaryotic origin of select groups and preferential association with transcription factor-encoding genes

Homology group

mORF: known or probable molecular function/domain

Known or inferred biological process

Source

uORF conserved in Arabidopsis and rice

1

bZIP transcription factor

Sucrose regulation

[89]

2

bHLH transcription factor

Transcriptional control

[68]

3

AdoMetDC

Polyamine biosynthesis: developmental regulation

[1]

4

Unknown; plant-specific

Unknown

BLAST analysis

5

Ankyrin repeat protein

Unknown

Protein domain analysis*

6

Amine oxidase

Unknown

Protein domain analysis*

7

Putative translation initiation factor eIF5

Start codon selection

Protein domain analysis*

8

Similar to Mic-1

Unknown

BLAST analysis

9

Unknown, cysteine-rich

Unknown (Possible novel zinc finger?)

CX4–7CX10CX2HX5 tandem repeats

10

MAP kinase

Signal transduction

PlantsP database

11

Trehalose-6-phosphate phosphatase

Trehalose metabolism: developmental regulation

[90]

12

Unknown

Systemically primed response to pathogens

[91]

13

Phosphoethanolamine N-methyltransferase

Phosphocholine biosynthesis

[38]

14

HDZip class I transcription factor

Transcriptional control; development

[92,93]

15

bHLH transcription factor

Transcriptional control; responsive to polyamine?

[52,68]

16

MAP kinase

Signal transduction

PlantsP database [99]

17

Unknown

Unknown

 

18

Transcription co-activator/repressor HsfB1

Mediator of heat shock response

[94,95]

19

SAUR protein

Mediator of auxin response; calmodulin (CaM) binding

IPR003676; [96]

uORF conserved in Arabidopsis paralogs

20

Unknown

Unknown

 

21

ERF/AP2 transcription factor

Putative regulator of pathogen resistance

[97,98]

22

Unknown

Unknown

 

23

MAP kinase

Signal transduction

PlantsP database [99]

24

Unknown

Unknown

 

25

Calcium response protein kinase

Ca++/CaM-dependent signal transduction

PlantsP database [100]

26

RING finger (C3HC4-type zinc finger)

Ubiquitination; mediator of protein degradation

Protein domain analysis*

  1. bZIP, basic leucine zipper; bHLH, basic helix-loop-helix; AdoMetDC, S-Adenosylmethionine decarboxylase; Mic-1, colon cancer-associated protein macrophage-inhibitory cytokine 1; MAP kinase, mitogen activated protein kinase; HDZip, homeodomain leucine zipper; ERF/AP2, ethylene response factor/apetala2.
  2. *As determined by InterProScan and NCBI conserved domains search.