Skip to main content

Table 4 Human LIM, POU, HNF, SINE, TALE, CUT, PROS, ZF AND CERS class homeobox genes and pseudogenes

From: Classification and nomenclature of all human homeobox genes

Human LIM-class homeobox genes
Family Gene symbol Gene name Location Entrez gene ID Previous symbols
Isl ISL1 ISL LIM homeobox 1 5q11.2 3670  
  ISL2 ISL LIM homeobox 2 15q24.3 64843  
Lhx1/5 LHX1 LIM homeobox 1 17q12 3975 LIM1
  LHX5 LIM homeobox 5 12q24.13 64211  
Lhx2/9 LHX2 LIM homeobox 2 9q33.3 9355 LH2
  LHX9 LIM homeobox 9 1q31.3 56956  
Lhx3/4 LHX3 LIM homeobox 3 9q34.3 8022 M2-LHX3
  LHX4 LIM homeobox 4 1q25.3 89884 GSH4
Lhx6/8 LHX6 LIM homeobox 6 9q33.2 26468 LHX6.1
  LHX8 LIM homeobox 8 1p31.1 431707 LHX7
Lmx LMX1A LMX LIM homeobox 1A 1q24.1 4009 LMX1, LMX1.1
  LMX1B LMX LIM homeobox 1B 9q33.3 4010 LMX2, LMX1.2
Human POU-class homeobox genes and pseudogenes
Hdx HDX highly divergent homeobox Xq21.1 139324 CXorf43
Pou1 POU1F1 POU class 1 homeobox 1 3p11.2 5449 PIT1, GHF1
Pou2 POU2F1 POU class 2 homeobox 1 1q24.2 5451 OCT1, OTF1
  POU2F2 POU class 2 homeobox 2 19q13.2 5452 OCT2, OTF2
  POU2F3 POU class 2 homeobox 3 11q23.3 25833 OCT11, PLA1, EPOC1, SKN1A
Pou3 POU3F1 POU class 3 homeobox 1 1p34.3 5453 OCT6, OTF6, SCIP
  POU3F2 POU class 3 homeobox 2 6q16.2 5454 OCT7, OTF7, BRN2, POUF3
  POU3F3 POU class 3 homeobox 3 2q12.1 5455 OTF8, BRN1
  POU3F4 POU class 3 homeobox 4 Xq21.1 5456 OTF9, BRN4
Pou4 POU4F1 POU class 4 homeobox 1 13q31.1 5457 BRN3A, RDC1, Oct-T1
  POU4F2 POU class 4 homeobox 2 4q31.22 5458 BRN3B, BRN3.2
  POU4F3 POU class 4 homeobox 3 5q32 5459 BRN3C
Pou5 POU5F1 POU class 5 homeobox 1 6p21.33 5460 OCT3, OTF3, OCT4, OTF4
  POU5F1P1 POU class 5 homeobox 1 pseudogene 1 8q24.21 5462 OTF3C, OTF3P1, POU5FLC8
  POU5F1P2 POU class 5 homeobox 1 pseudogene 2 8q22.3 100009665  
  POU5F1P3 POU class 5 homeobox 1 pseudogene 3 12p13.31 642559 OTF3L, POU5F1L, POU5FLC12
  POU5F1P4 POU class 5 homeobox 1 pseudogene 4 1q22 645682 POU5FLC1
  POU5F1P5 POU class 5 homeobox 1 pseudogene 5 10q21.3 100009667  
  POU5F1P6 POU class 5 homeobox 1 pseudogene 6 3q21.3 100009668  
  POU5F1P7 POU class 5 homeobox 1 pseudogene 7 3q12.1 100009669  
  POU5F1P8 POU class 5 homeobox 1 pseudogene 8 17q25.3 100009670  
  POU5F2 POU class 5 homeobox 2 5q15 134187 SPRM1
Pou6 POU6F1 POU class 6 homeobox 1 12q13.13 5463 BRN5, MPOU, TCFB1
  POU6F2 POU class 6 homeobox 2 7p14.1 11281 WT5, WTSL, RPF1
Human HNF-class homeobox genes
Hmbox HMBOX1 homeobox containing 1 8p12 79618 HNF1LA, PBHNF
Hnf1 HNF1A HNF1 homeobox A 12q24.31 6927 TCF1, HNF1, LFB1
  HNF1B HNF1 homeobox B 17q12 6928 TCF2, LFB3, VHNF1
Human SINE-class homeobox genes
Six1/2 SIX1 SIX homeobox 1 14q23.1 6495  
  SIX2 SIX homeobox 2 2p21 10736  
Six3/6 SIX3 SIX homeobox 3 2p21 6496  
  SIX6 SIX homeobox 6 14q23.1 4990 OPTX2, Six9
Six4/5 SIX4 SIX homeobox 4 14q23.1 51804 AREC3
  SIX5 SIX homeobox 5 19q13.32 147912 DMAHP
Human TALE-class homeobox genes and pseudogenes
Irx IRX1 iroquois homeobox 1 5p15.33   IRX-5
  IRX1P1 iroquois homeobox 1 pseudogene 1 13q12.12 79192 IRXA1
  IRX2 iroquois homeobox 2 5p15.33 646390  
  IRX3 iroquois homeobox 3 16q12.2 153572 IRX-1
  IRX4 iroquois homeobox 4 5p15.33 50805  
  IRX4P1 iroquois homeobox 4 pseudogene 1 18p11.22 100009671  
  IRX5 iroquois homeobox 5 16q12.2 79190 IRX2A
  IRX6 iroquois homeobox 6 16q12.2   IRX-3, IRX7
Meis MEIS1 Meis homeobox 1 2p14 4211  
  MEIS2 Meis homeobox 2 15q14 4212 MRG1
  MEIS3 Meis homeobox 3 19q13.32 56917 MRG2
  MEIS3P1 Meis homeobox 3 pseudogene 1 17p12 4213 MRG2, MEIS3, MEIS4
  MEIS3P2 Meis homeobox 3 pseudogene 2 17p11.2 257468  
Mkx MKX mohawk homeobox 10p12.1 283078 IRXL1, IFRX, C10orf48
Pbx PBX1 pre-B-cell leukemia homeobox 1 1q23.3 5087  
  PBX2 pre-B-cell leukemia homeobox 2 6p21.32 5089 G17, HOX12, PBX2MHC
  PBX2P1 pre-B-cell leukemia homeobox 2 pseudogene 1 3q24 5088 PBXP1, PBX2
  PBX3 pre-B-cell leukemia homeobox 3 9q33.3 5090  
  PBX4 pre-B-cell leukemia homeobox 4 19p13.11 80714  
Pknox PKNOX1 PBX/knotted homeobox 1 21q22.3 5316 PREP1, PKNOX1C
  PKNOX2 PBX/knotted homeobox 2 11q24.2 63876 PREP2
Tgif TGIF1 TGFB-induced factor homeobox 1 18p11.31 7050 TGIF, HPE4
  TGIF1P1 TGFB-induced factor homeobox1 pseudogene 1 19q13.32 126052  
  TGIF2 TGFB-induced factor homeobox 2 20q11.23 60436  
  TGIF2P1 TGFB-induced factor homeobox 2 pseudogene 1 1q44 126826  
  TGIF2P2 TGFB-induced factor homeobox 2 pseudogene 2 15q21.1 100009674  
  TGIF2P3 TGFB-induced factor homeobox 2 pseudogene 3 15q21.1 100009672  
  TGIF2P4 TGFB-induced factor homeobox 2 pseudogene 4 14q24.2 100009673  
  TGIF2LX TGFB-induced factor homeobox 2-like, X-linked Xq21.31 90316 TGIFLX (retrogene)
  TGIF2LY TGFB-induced factor homeobox 2-like, Y-linked Yp11.2 90655 TGIFLY (retrogene)
Human CUT-class homeobox genes and pseudogenes
Onecut ONECUT1 one cut homeobox 1 15q21.3 3175 HNF6, HNF6A
  ONECUT2 one cut homeobox 2 18q21.31 9480 OC2
  ONECUT3 one cut homeobox 3 19p13.3 390874  
Cux CUX1 cut-like homeobox 1 7q22.1 1523 CUTL1, CUX, CDP, COY1
  CUX2 cut-like homeobox 2 12q24.12 23316 CUTL2
  CUX2P1 cut-like homeobox 2 pseudogene 1 10p14 -  
  CUX2P2 cut-like homeobox 2 pseudogene 2 4q32.1 -  
Satb SATB1 SATB homeobox 1 3p24.3 6304  
  SATB2 SATB homeobox 2 2q33.1 23314  
Human PROS-class homeobox genes
Prox PROX1 prospero homeobox 1 1q41 5629  
  PROX2 prospero homeobox 2 14q24.3 283571  
Human ZF-class homeobox genes and pseudogenes
Adnp ADNP activity-dependent neuroprotector homeobox 20q13.13 23394 ADNP1
  ADNP2 ADNP homeobox 2 18q23 22850 ZNF508
Tshz TSHZ1 teashirt zinc finger homeobox 1 18q22.3 10194 TSH1
  TSHZ2 teashirt zinc finger homeobox 2 20q13.2 128553 TSH2, ZNF218, ZABC2, OVC10-2
  TSHZ3 teashirt zinc finger homeobox 3 19q12 57616 TSH3, ZNF537
Zeb ZEB1 zinc finger E-box binding homeobox 1 10p11.22 6935 ZFHX1A, deltaEF1, TCF8, ZEB
  ZEB2 zinc finger E-box binding homeobox 2 2q22.3 9839 ZFHX1B, SIP1, SMADIP1
  ZEB2P1 zinc finger E-box binding homeobox 2 pseudogene 1 4p15.32 100033412  
Zfhx ZFHX2 zinc finger homeobox 2 14q11.2 85446  
  ZFHX3 zinc finger homeobox 3 16q22.3 463 ATBT, ATBF1
  ZFHX4 zinc finger homeobox 4 8q21.11 79776 ZFH4
Zhx/ ZHX1 zinc fingers and homeoboxes 1 8q24.13 11244  
Homez ZHX2 zinc fingers and homeoboxes 2 8q24.13 22882  
  ZHX3 zinc fingers and homeoboxes 3 20q12 23051 TIX1
  HOMEZ homeobox and leucine zipper encoding 14q11.2 57594  
Human CERS-class homeobox genes
Cers CERS2 ceramide synthase 2 1p36.13-q24.1 29956 LASS2, TRH3, TMSG1
  CERS3 ceramide synthase 3 15q26.3 204219 LASS3
  CERS4 ceramide synthase 4 19p13.3 79603 LASS4, TRH1
  CERS5 ceramide synthase 5 12q13.12 91012 LASS5, TRH4
  CERS6 ceramide synthase 6 2q31 253782 LASS6
  1. Human homeobox genes and pseudogenes, excepting the ANTP and PRD classes, including full names, chromosomal locations, Entrez Gene IDs and previous symbols. The HOMEZ gene is in the ZF class but encodes a protein with leucine zippers instead of zinc fingers.