TY - JOUR AU - Okajima, Tetsuya AU - Reddy, BVVG AU - Matsuda, Tsukasa AU - Irvine, Kenneth D. PY - 2008 DA - 2008/01/14 TI - Contributions of chaperone and glycosyltransferase activities of O-fucosyltransferase 1 to Notch signaling JO - BMC Biology SP - 1 VL - 6 IS - 1 AB - O-fucosyltransferase1 (OFUT1) is a conserved ER protein essential for Notch signaling. OFUT1 glycosylates EGF domains, which can then be further modified by the N-acetylglucosaminyltransferase Fringe. OFUT1 also possesses a chaperone activity that promotes the folding and secretion of Notch. Here, we investigate the respective contributions of these activities to Notch signaling in Drosophila. SN - 1741-7007 UR - https://doi.org/10.1186/1741-7007-6-1 DO - 10.1186/1741-7007-6-1 ID - Okajima2008 ER -