Figure 5

Algorithm-based gene regulatory network structure for dorsal and ventral telencephalon development. The Bayesian-based TAO-Gen algorithm was implemented with an informative prior structure to predict the optimal network structure based on the LOF and GOF microarray datasets, evolutionarily conserved TFBS data, prior literature-based knowledge, and spatial and time-specific expression patterns. To highlight the key regulators, the nodes representing genes predicted to be the parent of at least nine other genes are largest in size (Sox9, Mef2a, Elavl4 and Pou6f1), whereas those that are predicted to regulate at least five other genes are medium in size (Ngn2, Centg3, Tef, Tcf4, Wnt7b, Pou2f1, Yy1, Dll1, E2f1, Arx, and Creb). See Additional file 11 for matrix of connectivity and Methods for a more detailed description of algorithm.