Metabolite functional group responses to copper, concentrations expressed as a percentage of the mean control value. (A) Lipophilic amino acids: black = aliphatic; blue = aromatic. (B) Cell membrane-related metabolites. Black = Bet, PE, Gly, HEFS; red = m-Ins, s-Ins. (C) Nucleosides. Blue = Nic, Uri; red = Xan, Ino; Black = Ado. (D) Organic acids. Blue = Mal, Fum, Succ; black = Ac; red = Lac. (E) Sugars and sugar phosphates. Blue = Mann; Red = Gluc; Black = G6P.