Figure 4
From: Erythropoietin enhances hippocampal long-term potentiation and memory
Neurophysiology of acute hippocampal slices: Intracellular recordings. (a-c) EPO enhances inhibitory transmission. (a) Representative recordings of spontaneous, pharmacologically isolated inhibitory postsynaptic currents (sIPSCs) from CA1 neurons. (b) Averaged amplitude of sIPSCs is not significantly altered in EPO-treated mice (N = 6 neurons/5 mice) compared to control (N = 4 neurons/4 mice; P = 0.0869). (c) Averaged frequency of sIPSCs is significantly enhanced in EPO-treated mice (N = 6 neurons/5 mice) compared to control (N = 4 neurons/4 mice). (d-f) EPO decreases excitatory transmission. (d) Representative recordings of spontaneous, pharmacologically isolated excitatory postsynaptic currents (sEPSCs) from CA1 neurons. (e) Averaged amplitude of sEPSCs is significantly decreased in EPO-treated mice (N = 4 neurons/4 mice) compared to control (N = 4 neurons/3 mice). (f) averaged frequency of sEPSCs is significantly decreased in EPO-treated mice (N = 4 neurons/4 mice) compared to control (N = 4 neurons/3 mice).