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Figure 3 | BMC Biology

Figure 3

From: Docosahexaenoic and eicosapentaenoic acids increase prion formation in neuronal cells

Figure 3

The effects of DHA or EPA are not reversed by mevalonate. (A) The amounts of free cholesterol in extracts from ScGT1 cells treated for 7 days with control medium, 5 μM simvastatin (Sim), 1 μM DHA or 1 μM EPA as shown (□), and with the addition of 100 μM mevalonate (■). Values shown are the mean average amounts of free cholesterol (ng/ml) ± SD, n = 9. # = amounts of free cholesterol significantly higher following the addition of mevalonate. (B) The amounts of PrPSc in ScGT1 cells treated for 7 days with control medium, 5 μM simvastatin (Sim), 1 μM DHA, 1 μM EPA as shown (□) and with the addition of 100 μM mevalonate (■). Values shown are the mean average amounts of PrPSc (ng/ml) ± SD, n = 9. # = amounts of PrPSc significantly higher following the addition of mevalonate.

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