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Figure 3 | BMC Biology

Figure 3

From: The molecular basis of defective lens development in the Iberian mole

Figure 3

Haematoxylin staining on mole wax sections. In the Iberian mole, the lens placode is established at the end of the s3 stage, that is, about 13 days post-coitum (dpc) and it rapidly invaginates forming the lens pit (s4a, 14 dpc). At s5a (17 dpc), the lens is clearly polarised and the posterior cells have already begun to elongate. About 5 days later (s7, about 22 dpc), lens fibre cells have not reached the centre of the lens epithelium (arrow). Lens occlusion has not been completed at the last prenatal stage (s8, about 26 dpc), as a small lens cavity is still observed (arrow). After birth, several vacuoles in the epithelium/fibre cells boundary (arrowheads) are seen in the lens of newborn moles (s9, 1 day post-partum), a situation maintained until adulthood (not shown). Scale bar represents 100 μm in all figures.

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